Human chorionic gonadotropin decreases cerebral cystic encephalomalacia and parvalbumin interneuron degeneration in a pro-inflammatory model of mouse neonatal hypoxia-ischemia.
Ben MillerAlexander CriderBhooma R AravamuthanRafael GalindoPublished in: bioRxiv : the preprint server for biology (2024)
Intraperitoneal administration of human chorionic gonadotropin (hCG) decreases lipopolysaccharide (LPS)-augmented hypoxic-ischemic neurodegeneration in the term-equivalent mouse neonatePretreatment with hCG reduces LPS-mediated cystic encephalomalacia of the cerebral cortex and ameliorates hippocampal tissue loss after neonatal hypoxia-ischemia (HI)hCG decreases LPS+HI-mediated parvalbumin immunoreactive interneuron loss in the cerebral cortex, hippocampus and dorsal striatum.hCG decreases LPS+HI-augmented microglial Iba1 immunoreactivity in the cerebral cortex and hippocampus.
Keyphrases
- inflammatory response
- cerebral ischemia
- endothelial cells
- subarachnoid hemorrhage
- anti inflammatory
- lps induced
- functional connectivity
- lipopolysaccharide induced
- brain injury
- induced pluripotent stem cells
- neuropathic pain
- blood brain barrier
- pluripotent stem cells
- spinal cord
- preterm infants
- prefrontal cortex
- cognitive impairment
- spinal cord injury
- mouse model