Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women.
Ghazala ShaheenSarwat JahanQurat Ul AinAsad UllahTayyaba AfsarAli AlmajwalIftikhar AlamSuhail RazakPublished in: Molecular genetics & genomic medicine (2019)
Considering the results of current study, it is concluded that decreased eNOS expression and oxidative stress could play a role in the pathology of PE seen both in placenta and ultimately in maternal endothelium. However, large studies are necessary to validate these findings to prevent maternal and neonatal morbidity and mortality in Pakistani population.
Keyphrases
- nitric oxide synthase
- oxidative stress
- nitric oxide
- pregnancy outcomes
- poor prognosis
- endothelial cells
- birth weight
- dna damage
- polycystic ovary syndrome
- diabetic rats
- pregnant women
- binding protein
- ischemia reperfusion injury
- induced apoptosis
- long non coding rna
- early onset
- physical activity
- signaling pathway
- case control
- preterm birth
- cervical cancer screening
- heat stress