Pancancer cytotoxic T cell trapping: Are neutrophil extracellular traps a viable biomarker for immunotherapy response?†.

In a recent issue of The Journal of Pathology, a study by de Andrea et al demonstrates the presence of neutrophil extracellular traps (NETs) in a variety of human solid tumor types detected by multiplex immunofluorescence. In addition to NET identification and quantification, they find that there is individual heterogeneity in NET abundance in tumors and in circulation, and that NETs are positively associated with IL-8 and negatively associated with tumor-infiltrating CD8+ T cells. This article is protected by copyright. All rights reserved.