Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.

Juan de Los Santos-JiménezJosé A Campos-SandovalClara Márquez-TorresNieves Urbano-PoloDavid BrøndegaardMercedes Martín-RufiánCarolina LoboAna PeñalverMaría C Gómez-GarcíaJanet Martín-CamposCarolina CardonaLaura CastillaFelipe da Costa SouzaTzuling ChengJuan A SeguraFrancisco J AlonsoRui CuriAlison ColquhounRalph J DeBerardinisJavier MárquezJosé M Matés

Published in: Journal of biomedical science (2021)

Glutaminase isoenzymes are related to the expression of some miRNAs and may contribute to either tumour progression or suppression through certain miRNA-mediated pathways, proving to be a key tool to switch cancer proliferation and redox status leading to a less malignant phenotype. Accordingly, GLS and GAB expression are especially involved in glutathione-dependent antioxidant defence.

Keyphrases

poor prognosis
induced apoptosis
oxidative stress
signaling pathway
long non coding rna
squamous cell carcinoma
cell proliferation