Integrated analysis of gene expression changes associated with coronary artery disease.
Liu MiaoRui-Xing YinFeng HuangShuo YangWu-Xian ChenJin-Zhen WuPublished in: Lipids in health and disease (2019)
The relative expression of IL1B, ICAM1 and CCL2 was higher in CAD than in normal controls (P < 0.05-0.001), but only IL1B and CCL2 genes were confirmed after testing the gene expression in blood and/or analyzing in Cox proportional hazards regression (P < 0.05-0.001), and the proper mechanism may involve in the AGE-RAGE signaling pathway, fluid shear stress, the tumor necrosis factor (TNF) and cytokine-cytokine receptor interaction.
Keyphrases
- gene expression
- coronary artery disease
- signaling pathway
- rheumatoid arthritis
- dna methylation
- liver fibrosis
- liver injury
- poor prognosis
- genome wide
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- binding protein
- pi k akt
- drug induced
- cardiovascular disease
- induced apoptosis
- endoplasmic reticulum stress
- bioinformatics analysis
- oxidative stress
- ejection fraction