Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection.
Yuanyang ChenXu LiZhi-Wei WangShun YuanXiaoyan ShenXiaoping XieKai XingQingyi ZhuPublished in: Molecular medicine (Cambridge, Mass.) (2024)
The survival period of ID mice was significantly shortened and the pathological staining results were the worst. Transcriptomic sequencing indicated that HIF1 was closely related to ID and the experimental results indicated that ID might regulate HIF1 expression by affecting oxygen balance. HIF1 activation regulates the phenotypic transformation of VSMC and participates in the occurrence and development of AD in vivo and in vitro.PX478, the inhibition of HIF1, can improve ID-induced AD exacerbation.
Keyphrases
- endothelial cells
- signaling pathway
- aortic dissection
- single cell
- iron deficiency
- chronic obstructive pulmonary disease
- high glucose
- poor prognosis
- risk assessment
- cell proliferation
- diabetic rats
- rna seq
- drug induced
- oxidative stress
- induced apoptosis
- free survival
- skeletal muscle
- stress induced
- extracorporeal membrane oxygenation