Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes.

Wendy E PowellStephanie J HannaClaire N HocterEmma RobinsonJoanne DaviesGareth J DunseathStephen LuzioDaniel FarewellLi WenColin M DayanDavid A PriceKristin LadellFlorence Susan Wong

Published in: Diabetologia (2018)

Our data reveal a statistically robust set of abnormalities that indicate an association between type 1 diabetes and long-term dysregulation of a chemokine ligand/receptor system that controls B cell migration.

Keyphrases

cell migration
type diabetes
glycemic control
poor prognosis
cardiovascular disease
binding protein
insulin resistance
electronic health record
genome wide
working memory
big data
gene expression
metabolic syndrome
deep learning