We report herein a synthesis of allylic phosphoramidates from alkenes by selenium-catalyzed allylic C-H derivatization. This method features mild conditions, broad substrate scope, and high functional group tolerance, enabling late-stage modification of a number of complex substrates. In addition, this protocol was applied to modify caryophyllene and produced a photoaffinity probe capable of proteomic target labeling in live HeLa cells.
Keyphrases
- cell cycle arrest
- induced apoptosis
- room temperature
- randomized controlled trial
- cell death
- ms ms
- high performance liquid chromatography
- endoplasmic reticulum stress
- living cells
- gas chromatography mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- simultaneous determination
- gas chromatography
- amino acid
- mass spectrometry
- label free