Systemic Therapy for Patients with HER2-Positive Breast Cancer and Brain Metastases: A Systematic Review and Meta-Analysis.

Inge M WerterSharon RemmelzwaalGeorge Louis BurchellTanja D de GruijlInge R KoningsHans J van der VlietCatharina Willemien Menke-van der Houven van Oordt

Published in: Cancers (2022)

Though our meta-analysis should be interpreted with caution due to the heterogeneity of included studies and a related serious risk of bias, this review provides a comprehensive overview of all currently available systemic treatment options. T-Dxd and TTC that appear to constitute the most effective systemic therapy in patients with HER2+ mBC and BM, while pyrotinib might be an option in Asian patients.

Keyphrases

positive breast cancer
brain metastases
systematic review
end stage renal disease
small cell lung cancer
chronic kidney disease
ejection fraction
newly diagnosed
case control
peritoneal dialysis
randomized controlled trial
single cell
stem cells
drug induced
meta analyses
patient reported outcomes