Activation of Estrogen Receptor G Protein-Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice.

Helen H WangOrnella de BariChristopher K ArnattMin LiuPiero PortincasaDavid Q-H Wang

Published in: Hepatology (Baltimore, Md.) (2020)

GPR30 produces additional lithogenic actions, working independently of ERα, to increase susceptible to gallstone formation in female mice; both GPR30 and ERα are potential therapeutic targets for cholesterol gallstone disease, particularly in women and patients exposed to high levels of estrogen.

Keyphrases

estrogen receptor
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
high fat diet induced
fatty acid
low density lipoprotein
prognostic factors
polycystic ovary syndrome
peritoneal dialysis
metabolic syndrome
insulin resistance
risk assessment
wild type