Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex.
Maria Isabel Navarro-MendozaCarlos Pérez-ArquesJosie E ParkerZiyan XuSteven L KellyJoseph HeitmanPublished in: mBio (2024)
mutants survive within the host and disseminate the infection, indicating that Erg6a deficiency may arise during human infections and confer resistance to the most effective treatment against mucormycoses.