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Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex.

Maria Isabel Navarro-MendozaCarlos Pérez-ArquesJosie E ParkerZiyan XuSteven L KellyJoseph Heitman
Published in: mBio (2024)
mutants survive within the host and disseminate the infection, indicating that Erg6a deficiency may arise during human infections and confer resistance to the most effective treatment against mucormycoses.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • candida albicans
  • combination therapy
  • antimicrobial resistance