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Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury.

Dongsheng WangXiaojing LiWenxi LiTiffany DuongHongxia WangNatalia KleschevnikovaHemal H PatelEllen BreenSusan PowellShanshan WangBrian P Head
Published in: British journal of pharmacology (2024)
Post-injury chronic nicotine exposure via vaping facilitates recovery of sensorimotor function by upregulating neuroprotective mBDNF/TrkB/Akt/Erk signalling. These findings suggest potential neuroprotective properties of nicotine despite its highly addictive nature. Thus, understanding the multifaceted effects of chronic nicotine exposure on TBI-associated symptoms is crucial for paving the way for informed and properly managed therapeutic interventions.
Keyphrases
  • smoking cessation
  • traumatic brain injury
  • signaling pathway
  • cerebral ischemia
  • cell proliferation
  • functional connectivity
  • pi k akt
  • depressive symptoms
  • mild traumatic brain injury