Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme.
Chris WatsonJ Paul SpiersMax WaterstoneAdam Russell-HallinanJoseph GallagherKenneth McDonaldCristin RyanJohn GilmerMark LedwidgePublished in: BMC cardiovascular disorders (2021)
Diabetes patients with the minor T allele of rs3918242 in the STOP-HF follow up programme have greater risk of myocardial infarction, lower ejection fraction and greater progression of left ventricular systolic abnormalities, a precursor to heart failure. These data may support further work on MMP-9 as a biomarker of ventricular dysfunction and the investigation of MMP-9 inhibitors for heart failure prevention in diabetes, particularly in the post-infarction setting. ClinicalTrials.gov Identifier: NCT00921960.
Keyphrases
- left ventricular
- heart failure
- ejection fraction
- aortic stenosis
- acute heart failure
- cardiac resynchronization therapy
- type diabetes
- cardiovascular disease
- hypertrophic cardiomyopathy
- glycemic control
- blood pressure
- acute myocardial infarction
- oxidative stress
- study protocol
- mitral valve
- left atrial
- cell migration
- randomized controlled trial
- electronic health record
- clinical trial
- insulin resistance
- big data
- machine learning
- data analysis
- gene expression
- transcatheter aortic valve replacement
- coronary artery disease
- aortic valve