The use of cell culture platforms to identify novel markers of bone and dentin resorption.
Wellington J RodyO KrokhinV SpicerC A ChamberlainM ChamberlainK P McHughS M WalletA K EmoryJ D CrullLexie Shannon HollidayPublished in: Orthodontics & craniofacial research (2018)
Our data suggest that the mineralized matrix type plays a role in the final phenotypic characteristics of mouse clastic cells. Many in vitro biomarker candidates of bone and dentin resorption can also be found in human oral fluids, thus indicating that this approach may be a viable alternative in biomarker discovery.
Keyphrases
- bone loss
- bone regeneration
- bone mineral density
- induced apoptosis
- endothelial cells
- cell cycle arrest
- soft tissue
- small molecule
- electronic health record
- high throughput
- induced pluripotent stem cells
- big data
- postmenopausal women
- signaling pathway
- pluripotent stem cells
- oxidative stress
- body composition
- cell death
- cell proliferation
- deep learning
- single cell
- pi k akt