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ARID1A regulates E-cadherin expression in colorectal cancer cells: a promising candidate therapeutic target.

Mehran ErfaniMozhdeh ZamaniSeyed Younes HosseiniZohreh Mostafavi-PourSayed Mohammad ShafieeMohammadreza SaeidniaPooneh Mokarram
Published in: Molecular biology reports (2021)
Our study demonstrates that E-cadherin levels were closely correlated with ARID1A expression. Thus, ARID1A downregulation may promote CRC metastasis through decreasing EMT‑related protein E-cadherin and promoting epithelial cell movement. ARID1A could represent a promising candidate therapeutic target for CRC.
Keyphrases
  • poor prognosis
  • epithelial mesenchymal transition
  • cell proliferation
  • long non coding rna