ARID1A regulates E-cadherin expression in colorectal cancer cells: a promising candidate therapeutic target.
Mehran ErfaniMozhdeh ZamaniSeyed Younes HosseiniZohreh Mostafavi-PourSayed Mohammad ShafieeMohammadreza SaeidniaPooneh MokarramPublished in: Molecular biology reports (2021)
Our study demonstrates that E-cadherin levels were closely correlated with ARID1A expression. Thus, ARID1A downregulation may promote CRC metastasis through decreasing EMT‑related protein E-cadherin and promoting epithelial cell movement. ARID1A could represent a promising candidate therapeutic target for CRC.