Case Report: Bocavirus Infection Radiologically Resembling a Congestive Heart Failure in a Patient with Metastatic Castration-Resistant Prostate Cancer Case-Report.
Javier David Benitez FuentesAlicia de Luna AguilarPaloma Flores NavarroAlfonso Lopez de Sa LorenzoCarmen Toledano RojasBerta Laguna FonsecaRicha ShahClara FrickAlejandro Francisco Jimenez OrtegaNatalia Vidal CassinelloPublished in: F1000Research (2022)
Background: Human bocavirus (HBoV) is a viral pathogen from the genus Bocaparvovirus (family Parvoviridae , subfamily Parvovirinae ) discovered in 2005. Most of available literature is about HBoV in children and adults with hematological malignancies and in otherwise healthy children with respiratory infections. Information regarding infection in the adult population with solid tumors is scarce. Case Report: We report the case of a 51-year-old male with metastatic castration resistant prostate cancer undergoing chemotherapy treatment who presented with fever, dyspnea, dry cough, and pleuritic pain. Imaging techniques showed signs of congestive heart failure. Symptoms, laboratory tests and echocardiography revealed a more probable infectious etiology. Antibiotic therapy was started. A polymerase chain reaction (PCR) test of nasopharyngeal exudate for respiratory viruses was positive for HBoV. The rest of the microbiological tests were negative. Bronchoalveolar lavage (BAL) was performed. Bacterial culture of BAL was negative while respiratory virus PCR confirmed positivity for HBoV. Antibiotic therapy was discontinued. The patient gradually recovered. Conclusions: Emerging infectious diseases are a notorious threat for immunocompromised populations such as solid tumor patients. This case is unique because to our knowledge this is the first case report article of HBoV in a solid tumor patient and because imaging techniques exhibited signs of congestive heart failure that did not correlate with the rest of the tests. It shows that unusual pathogens should be considered when managing serious clinical complications with uncommon presentations in cancer patients. Notable diagnostic efforts should be made to reach a diagnosis in these cases.
Keyphrases
- case report
- heart failure
- left ventricular
- squamous cell carcinoma
- infectious diseases
- small cell lung cancer
- high resolution
- endothelial cells
- end stage renal disease
- systematic review
- newly diagnosed
- chronic pain
- radiation therapy
- chronic kidney disease
- stem cells
- intensive care unit
- spinal cord
- spinal cord injury
- mesenchymal stem cells
- acute heart failure
- depressive symptoms
- neuropathic pain
- risk factors
- multidrug resistant
- candida albicans
- smoking cessation
- advanced cancer
- rectal cancer
- patient reported