Transcriptional upregulation of CXCL13 is correlated with a favorable response to immune checkpoint inhibitors in lung adenocarcinoma.

Sehhoon ParkHongui ChaHong Sook KimBoram LeeSoyeon KimTae Min Kim Hyun Ae JungJong-Mu SunJin Seok AhnMyung-Ju AhnKeunchil ParkWoong-Yang ParkSe-Hoon Lee

Published in: Cancer medicine (2022)

We observed that CXCL13 upregulation is correlated to better ICI response in lung adenocarcinoma. Our results support that CXCL13 could be an important chemokine in shaping the immunoactive tumor microenvironment which affects the anti-tumor effect of ICI.

Keyphrases

poor prognosis
cell proliferation
signaling pathway
gene expression
long non coding rna