Cerebrospinal Fluid Iron-Ferritin Ratio as a Potential Progression Marker for Parkinson's Disease.

Fabian MaassBernhard MichalkeDesiree WillkommenSezgi CanaslanMatthias SchmitzMathias BährInga ZerrPaul Lingor

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Longitudinal PD CSF samples were subjected to ICP-MS and the total amount of iron and other bioelements was quantified. Additionally, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increased while levels of ferritin decreased.

Keyphrases

iron deficiency
cerebrospinal fluid
mass spectrometry
multiple sclerosis
ms ms
cross sectional
protein protein
binding protein