Paclitaxel and Carboplatin in Combination with Low-Intensity Pulsed Ultrasound for Glioblastoma.

Karl John Habashy Crismita Dmello Li Chen Víctor A Arrieta Kwang-Soo Kim Andrew Gould Mark W Youngblood Guillaume Bouchoux Kirsten Bell Burdett M-Marsel Mesulam Michael Canney Roger Stupp Adam M Sonabend

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Combining paclitaxel and carboplatin in gliomas may be more efficacious than monotherapy, as in other cancers, due to synergy and independent susceptibility to each drug. These results form the basis for an ongoing phase II trial (NCT04528680) where we investigate this combination with LIPU/MB.

Keyphrases

phase ii study
open label
phase iii
high grade
magnetic resonance imaging
combination therapy
clinical trial
randomized controlled trial
chemotherapy induced
drug induced
locally advanced