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Who plays the ferryman: ATG2 channels lipids into the forming autophagosome.

Nicholas T Ktistakis
Published in: The Journal of cell biology (2019)
Expansion of the autophagosomal membrane requires a mechanism to supply lipids while excluding most membrane proteins. In this issue, Valverde et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201811139) identify ATG2, a member of the autophagy-related protein family, as a lipid transfer protein and provide important novel insights on how autophagosomes grow.
Keyphrases
  • fatty acid
  • single cell
  • cell death
  • endoplasmic reticulum stress
  • cell therapy
  • oxidative stress
  • signaling pathway
  • stem cells
  • amino acid
  • protein protein
  • electron transfer