NLRP6 suppresses the inflammatory response of human periodontal ligament cells by inhibiting NF-κB and ERK signal pathways.
W L LuLan ZhangD Z SongX W YiW Z XuL YeDingming HuangPublished in: International endodontic journal (2019)
NLRP6 was functionally expressed in inflamed periapical tissues and HPDLCs. NLRP6 negatively regulated the production of IL-6 and TNF-α in HPDLCs inflammation by inhibiting NF-κB and ERK signal pathways.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- inflammatory response
- cell cycle arrest
- nlrp inflammasome
- endothelial cells
- oxidative stress
- lps induced
- rheumatoid arthritis
- gene expression
- lipopolysaccharide induced
- transcription factor
- induced pluripotent stem cells
- pluripotent stem cells
- cell proliferation
- cone beam