Association between piperacillin/tazobactam use and acute kidney injury in critically ill patients: a retrospective multicentre cohort study.

Bruno Martins TomaziniBruno Adler Maccagnan Pinheiro BesenLeandro Utino TaniguchiFernando Godinho ZampieriAlexandre Biasi Cavalcanti

Published in: The Journal of antimicrobial chemotherapy (2024)

In critically ill patients, exposure to piperacillin/tazobactam was associated with increased risk of AKI and with increased risk of RRT, regardless of combination therapy with vancomycin.

Keyphrases

combination therapy
gram negative
acute kidney injury
clinical trial
study protocol
randomized controlled trial
multidrug resistant
double blind