Enhancing care for people living with HIV: current and future monitoring approaches.
Franco MaggioloAlessandra BanderaStefano BonoraMarco BorderiAndrea CalcagnoAnnamaria CattelanAntonella CingolaniNicola GianottiMiriam LichtnerSergio Lo CaputoGiordano MadedduPaolo MaggiGiulia Carla MarchettiRenato MaseratiSilvia NozzaStefano RusconiMaurizio ZazziAntonio Di BiagioPublished in: Expert review of anti-infective therapy (2020)
Viral load and CD4 counts are well-validated outcome measures and we still need them, but they do not completely depict the health status of PLWHIV. We need to better understand and to apply to clinical practice what happens in sanctuaries, what is the role of HIV DNA, what is the meaning of low-level viremia. Most of these questions do not yet have a definitive response. Further, we need to understand how to modify these variables in order to improve outcomes.Similar points may be raised for immunological measures and for tests exploring the tolerability of drugs. The goal must be the evolution from a viro/immunologic-based to a comprehensive quality-of-health-based evaluation of PLWHIV.
Keyphrases
- clinical practice
- healthcare
- antiretroviral therapy
- quality improvement
- hiv positive
- hiv infected
- public health
- hiv testing
- palliative care
- human immunodeficiency virus
- circulating tumor
- hepatitis c virus
- open label
- hiv aids
- advanced cancer
- cell free
- current status
- men who have sex with men
- single molecule
- mental health
- health information
- peripheral blood
- locally advanced
- double blind
- south africa
- human health
- metabolic syndrome
- drug induced
- radiation therapy
- placebo controlled
- skeletal muscle
- study protocol
- glycemic control
- health insurance