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Maternal obesity and high leptin levels prime pro-inflammatory pathways in human cord blood leukocytes.

Bernardo J KrauseFabian A Vega-TapiaGustavo Soto-CarrascoIsidora LefeverCatalina LetelierClaudia G SaezJose A Castro-Rodriguez
Published in: Placenta (2023)
Obesity in pregnancy is associated with a distinctive expression and DNA methylation profile of leptin-related genes in cord blood monocytes, meanwhile, leptin enhances the expression of pro-inflammatory cytokines upon stimulation with M1-skewing agents.
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