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A convergent structure-function substrate of cognitive imbalances in autism.

Seok-Jun HongLaurent MottronBo-Yong ParkOualid M BenkarimSofie Louise ValkCasey PaquolaSara LariviereReinder Vos de WaelJanie Degré-PelletierIsabelle SoulièresBruce RamphalAmy MargolisMichael Peter MilhamAdriana Di MartinoBoris C Bernhardt
Published in: Cerebral cortex (New York, N.Y. : 1991) (2022)
Although verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.
Keyphrases
  • autism spectrum disorder
  • intellectual disability
  • attention deficit hyperactivity disorder
  • randomized controlled trial
  • working memory
  • single cell
  • white matter
  • amino acid
  • healthcare
  • current status
  • cord blood