Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line.

Silvia PellegriniFabio ManentiRaniero ChimientiRita NanoLinda OttoboniFrancesca RuffiniGianvito MartinoPhilippe RavassardLorenzo PiemontiValeria Sordi

Published in: Cell transplantation (2018)

We demonstrated that insulin-producing cells generated from iPSCs recapitulate fundamental gene expression profiles and secretory function of native human β cells.

Keyphrases

induced apoptosis
cell cycle arrest
induced pluripotent stem cells
type diabetes
endothelial cells
endoplasmic reticulum stress
signaling pathway
gene expression
oxidative stress
adipose tissue
dna methylation
metabolic syndrome
genome wide identification
pluripotent stem cells