PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.

Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

Published in: Cancer research (2024)

PRMT1 promotes chemoresistance in TNBC by methylating metabolic enzymes PFKFB3, PKM2, and PHGDH to augment de novo fatty acid synthesis, indicating that targeting this axis is a potential treatment strategy.

Keyphrases

fatty acid
cancer therapy