DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures.
Monica Del C Gomez-AlonsoAnja KretschmerRory WilsonLiliane PfeifferVille KarhunenIlkka SeppäläWeihua ZhangKirstin MittelstraßSimone WahlPamela R Matias-GarciaHolger ProkischSacha HornThomas MeitingerLuis R Serrano-GarciaSylvain SebertOlli RaitakariMarie LohWolfgang RathmannMartina Müller-NurasyidChristian HerderMichael RodenMikko HurmeMarjo-Riitta JarvelinMika Ala-KorpelaJaspal S KoonerAnnette PetersTerho LehtimäkiJohn C ChambersChristian GiegerJohannes KettunenMelanie WaldenbergerPublished in: Clinical epigenetics (2021)
Our study provides evidence of a link between DNA methylation and the lipid compositions and lipid concentrations of different lipoprotein size subclasses, thus offering in-depth insights into well-known associations of DNA methylation with total serum lipids. The results support detailed profiling of lipid metabolism to improve the molecular understanding of dyslipidemia and related disease mechanisms.