Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer.

Anthony D SalehHui ChengScott E MartinHan SiPinar OrmanogluSophie CarlsonPaul E ClavijoXinping YangRita DasShaleeka CorneliusJamie CouperDouglas B Chepeha Ludmila V DanilovaThomas M HarrisMichael B PrystowskyGeoffrey J ChildsRichard V SmithA Gordon Robertson Steven J M Jones Andrew D CherniakSang S KimAntonina RaitKathleen F PirolloEsther H ChangZhong ChenCarter Van Waes

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We identify the miR-30 family as an important regulator of signal networks and tumor suppressor in a subset of HNSCC patients, which may benefit from miRNA replacement nanomedicine therapy.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
long non coding rna
cancer therapy
peritoneal dialysis
prognostic factors
genome wide
gene expression
bone marrow
patient reported outcomes
drug delivery
cell therapy