Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study.

Hossein SadeghiZeeba KamaliyanRoohollah MohseniUnes SahebiEhsan Nazemalhosseini-MojaradNaser AghaeiMohammad Reza ZaliHamid Asadzadeh AghdaeiReza Mirfakhraie Arfa Moshiri

Published in: Journal of clinical laboratory analysis (2020)

CYP2R1 and CYP27B1 genes were over-expressed in CRC samples compared to the adjacent control tissues. Furthermore, CYP2R1 rs12794714 variant was associated with the risk of CRC in the studied samples. CYP2R1 rs10766196 and CYP27B1 rs4646536 are not responsible for CYP2R1 and CYP27B1 genes expression alteration, respectively, but CYP2R1 rs12794714 polymorphism may be the reason of CYP2R1 upregulation and increased the risk of CRC.

Keyphrases

genome wide
poor prognosis
gene expression
cell proliferation
binding protein
genome wide analysis