Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla 1H-MRS study.
Wenbo WuSiyi XuJialin WangKuiming ZhangMingkun ZhangYang CaoHongqing RenDeyou ZhengChunlong ZhongPublished in: BMC neuroscience (2018)
Using two non-invasive methods, 1H-MRS and T2 MR imaging, as well as in vitro brain-water content measurements, we demonstrated that the mechanism underlying the neuroprotective effects of GCP II-KO against brain swelling in TBI involves changes in glutamate and N-acetylaspartate levels. This knowledge may contribute towards the development of therapeutic strategies for TBI.
Keyphrases
- wild type
- traumatic brain injury
- cerebral ischemia
- white matter
- resting state
- healthcare
- severe traumatic brain injury
- mild traumatic brain injury
- genome wide
- copy number
- subarachnoid hemorrhage
- magnetic resonance imaging
- gene expression
- dna methylation
- brain injury
- contrast enhanced
- computed tomography
- genome wide identification
- genome wide analysis