Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.

Matthieu JabaudonRaiko BlondonnetLaurence RoszykDamien BouvierJules AudardGael ClairefondMathilde FournierGeoffroy MarceauPierre DéchelotteBruno PereiraVincent SapinJean-Michel Constantin

Published in: American journal of respiratory and critical care medicine (2015)

Our results indicate that sRAGE levels could be a reliable predictor of impaired AFC during ARDS, and should stimulate further studies on the pathophysiologic implications of RAGE axis in the mechanisms leading to edema resolution. Clinical trial registered with www.clinicaltrials.gov (NCT 00811629).

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
clinical trial
mechanical ventilation
study protocol
open label
phase ii
randomized controlled trial
phase iii
intensive care unit
binding protein