Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer.
Samarth KansaraVijay PandeyPeter E LobieGautam SethiManoj GargAmit Kumar PandeyPublished in: Cells (2020)
Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and lack of targeted therapeutics are major hindrances to effective treatments in the clinic and are crucial causes of a worse prognosis and high rate of relapse/recurrence in patients diagnosed with TNBC. In the last decade, long non-coding RNAs (lncRNAs) have been found to perform a pivotal role in most cellular functions. The aberrant functional expression of lncRNAs plays an ever-increasing role in the progression of diverse malignancies, including TNBC. Therefore, lncRNAs have been recently studied as predictors and modifiers of chemoresistance. Our review discusses the potential involvement of lncRNAs in drug-resistant mechanisms commonly found in TNBC and highlights various therapeutic strategies to target lncRNAs in this malignancy.
Keyphrases
- long non coding rna
- poor prognosis
- drug resistant
- network analysis
- genome wide analysis
- genome wide identification
- multidrug resistant
- end stage renal disease
- ejection fraction
- acinetobacter baumannii
- newly diagnosed
- chronic kidney disease
- primary care
- free survival
- small molecule
- risk factors
- risk assessment
- young adults