Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
Ji Yeon LeeHaengseok SongOyunbileg DashMira ParkNa E ShinMichael W McLaneJun LeiJong Yun HwangIrina BurdPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury. These results suggest that melatonin, a safe treatment during pregnancy, may be used as an experimental therapeutic in clinical trials.
Keyphrases
- brain injury
- preterm birth
- gestational age
- birth weight
- subarachnoid hemorrhage
- low birth weight
- mouse model
- clinical trial
- immune response
- cerebral ischemia
- oxidative stress
- pregnant women
- pregnancy outcomes
- randomized controlled trial
- combination therapy
- toll like receptor
- body mass index
- blood brain barrier
- physical activity