Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.
Mathijs G A BroerenIrene Di CeglieMiranda B BenninkPeter L E M van LentWim B van den BergMarije I KoendersEsmeralda N Blaney DavidsonPeter M van der KraanFons A J van de LooPublished in: PeerJ (2018)
Gene therapy based on the expression of TSG-6 could not provide cartilage protection in experimental osteoarthritis, but instead resulted in increased ectopic bone formation.