A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation.

Wangteng Wu Qi-da HuMeng WangShiyi ShaoXinyu ZhaoHongzhen BaiJunming HuangGuping TangTingbo Liang

Published in: Chemical communications (Cambridge, England) (2019)

We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
long noncoding rna
stem cells
drug delivery
fluorescence imaging
fluorescent probe
photodynamic therapy
cell therapy
smoking cessation