Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway.
Celien TigchelaarMark L van ZuylenAbraham H HulstBenedikt PreckelAndré P van BeekIdo P KemaJeroen HermanidesAnthony R AbsalomPublished in: Diabetologia (2022)
Hyperglycaemia causes a proportional increase in polyol concentrations in CSF of patients without major neurological disease. Furthermore, this study provides the first indication of upregulation of the cerebral polyol pathway in patients with diabetes without evident neurological abnormalities.
Keyphrases
- cerebrospinal fluid
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- subarachnoid hemorrhage
- cerebral ischemia
- prognostic factors
- cell proliferation
- poor prognosis
- blood pressure
- blood glucose
- patient reported outcomes
- insulin resistance
- weight loss
- skeletal muscle
- glycemic control
- patient reported