Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE.

Qing XieTeli LiuJing DingNina ZhouXiangxi MengHua ZhuNan LiJiangyuan YuZhi Yang

Published in: European journal of nuclear medicine and molecular imaging (2021)

Qualitied [18F]AlF-NOTA-JR11 is prepared conveniently with reasonable yield, and it can bind SSTR2 specifically with high affinity. Excellent imaging capability of [18F]AlF-NOTA-JR11 for NENs is superior to [68Ga]Ga-DOTA-TATE, especially in digestive system. It has a great potential for imaging of NENs.

Keyphrases

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mesenchymal stem cells
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