Simple modeling of familial Alzheimer's disease using human pluripotent stem cell-derived cerebral organoid technology.

Mu Seog ChoeHan Cheol YeoJoong Sun KimJean LeeHae Jun LeeHyung-Ryong KimKyung Min BaekNa-Yeon JungMurim ChoiMin Young Lee

Published in: Stem cell research & therapy (2024)

Our model effectively recapitulates AD pathology. Hence, it is a valuable platform for understanding the mechanisms underlying AD pathogenesis and can be used to test the efficacy of anti-AD drugs.

Keyphrases

endothelial cells
early onset
cognitive decline
induced pluripotent stem cells
pluripotent stem cells
single cell