Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer.

Prakash C ThakurJennifer L Miller-OcuinKhanh NguyenRina MatsudaAatur D SinghiHerbert J ZehNathan Bahary

Published in: Journal of translational medicine (2018)

Sunitinib combined with chloroquine reduces tumor growth through suppression of autophagy and increased apoptosis. Co-administration of modulators of ER stress-mediated autophagy with chemotherapy presents a novel therapeutic approach in PDAC.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
randomized controlled trial
cell death
small molecule
oxidative stress
signaling pathway
renal cell carcinoma
locally advanced
pi k akt