BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.
Ming ZhangMin YangLi-ping LiuWayne Bond LauHai GaoMan-kun XinLi-Xiao SuJian WangShu-Juan ChengQian FanJing-Hua LiuPublished in: Oxidative medicine and cellular longevity (2014)
BMP-2 significantly increased VSMCs migration and myosin Va expression, via the Erk signaling pathway and intracellular Ca(2+) oscillations. We provide additional insight into the pathophysiology of atherosclerosis, and inhibition of BMP-2-induced myosin Va expression may represent a potential therapeutic strategy.
Keyphrases
- binding protein
- signaling pathway
- smooth muscle
- pi k akt
- mesenchymal stem cells
- poor prognosis
- cell proliferation
- bone regeneration
- epithelial mesenchymal transition
- cardiovascular disease
- single cell
- high glucose
- type diabetes
- induced apoptosis
- working memory
- cell therapy
- bone marrow
- transcription factor
- cystic fibrosis
- oxidative stress
- candida albicans