This systematic review summarizes the impact of cystic fibrosis (CF) on sexual and reproductive health (SRH) in males and females, covering pubertal development, hormonal function, family planning, and fertility. Included articles featured historical CF diagnostic criteria, preclinical or clinical data (retrospective cohorts or open label trials), while excluded articles lacked full text availability, explicit methodology, or comparisons between CF and non-CF patients. Genotype differences in CFTR mutations influenced symptom severity. Males with CF experienced delayed puberty, hypogonadism, infertility from obstructive azoospermia, and semen parameter issues. Female CF patients showed decreased fertility, possibly linked to disrupted ionic balance and ovarian cystic disease. Assistive reproductive technologies addressed fertility issues, but success varied based on disease severity and genotype. CFTR modulators aided pulmonary function and sexual health but require further assessment for fertility benefits.
Keyphrases
- cystic fibrosis
- pseudomonas aeruginosa
- systematic review
- lung function
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- open label
- type diabetes
- clinical trial
- mental health
- machine learning
- adipose tissue
- cross sectional
- childhood cancer
- mesenchymal stem cells
- bone marrow
- phase ii
- ionic liquid
- smoking cessation
- big data
- functional connectivity
- rectal cancer
- locally advanced