Randomized Trial of Botulinum Toxin Type A in Hereditary Spastic Paraplegia - The SPASTOX Trial.

Fabricio Diniz de LimaIngrid FaberKatiane R ServelhereMaria Fernanda R BittarAlberto R M MartinezLuiza G PiovesanaMelina P MartinsCarlos Roberto MartinsTatiana BenagliaBenilton de Sá CarvalhoAnamarli NucciMarcondes C França

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

BoNT-A was safe in patients with hereditary spastic paraplegias and reduced the adductor tone, but it was not able to produce functional improvement considering the doses, injection protocol, measures, and instruments used. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

botulinum toxin
study protocol
randomized controlled trial
clinical trial
phase iii
phase ii
patient reported outcomes
cerebral palsy