Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa .

biofilm formation through an interaction with PelD. This discovery adds to the growing body of literature regarding how hybrid GGDEF-EAL enzymes are regulated and provides additional precedence for studying how direct interactions between c-di-GMP metabolic enzymes and effectors result in signaling specificity.