P Lynne Howell (P L Howell)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 45

Top Venues

Journal of bacteriology

Nature communications

NPJ biofilms and microbiomes

Communications biology

Birkbeck University of London (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Birkbeck University of London

United Kingdom

PHD

University of Leeds

United Kingdom

BSC

Publications

Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Waleska S da Cruz Nizer, Kira N Allison, Madison E Adams, Mario A Vargas, Duale Ahmed, Carole Beaulieu, Deepa Raju, Edana Cassol, P Lynne Howell, Joerg Overhage
The role of exopolysaccharides Psl and Pel in resistance of Pseudomonas aeruginosa to the oxidative stressors sodium hypochlorite and hydrogen peroxide. Microbiology spectrum (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology (2024)
Jaime C Van Loon, Gregory B Whitfield, Nicole Wong, Lindsey O'Neal, Amy Henrickson, Borries Demeler, George A O'Toole, Matthew R Parsek, P Lynne Howell
Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa . Journal of bacteriology 206 (2) (2024)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
Erum Razvi, Benjamin R DiFrancesco, Gregory A Wasney, Zachary A Morrison, John Tam, Anick Auger, Perrin Baker, Noor Alnabelseya, Jacquelyn D Rich, Piyanka Sivarajah, Gregory B Whitfield, Joe Jonathan Harrison, Roman A Melnyk, Mark Nitz, P Lynne Howell
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation. Microbiology spectrum (2023)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
Alexander Eddenden, Manoj K Dooda, Zachary A Morrison, Adithya Shankara Subramanian, P Lynne Howell, Jerry M Troutman, Mark Nitz
The Metabolic Usage and Glycan Destinations of GlcNAz in E. coli . bioRxiv : the preprint server for biology (2023)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
Andreea A Gheorghita, Daniel J Wozniak, Matthew R Parsek, P Lynne Howell
Pseudomonas aeruginosa biofilm exopolysaccharides: Assembly, function, and degradation. FEMS microbiology reviews (2023)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
Gavin Melaugh, Vincent A Martinez, Perrin Baker, Preston J Hill, P Lynne Howell, Daniel J Wozniak, Rosalind J Allen
Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures. NPJ biofilms and microbiomes 9 (1) (2023)
Erum Razvi, Gregory B Whitfield, Courtney Reichhardt, Julia E Dreifus, Alexandra R Willis, Oxana B Gluscencova, Erin S Gloag, Tarek S Awad, Jacquelyn D Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C Sheppard, Benjamin D Hatton, Paul Stoodley, Aaron W Reinke, Gabrielle L Boulianne, Daniel J Wozniak, Joe Jonathan Harrison, Matthew R Parsek, P Lynne Howell
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes 9 (1) (2023)
François Le Mauff, Erum Razvi, Courtney Reichhardt, Piyanka Sivarajah, Matthew R Parsek, P Lynne Howell, Donald C Sheppard
The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine. Communications biology 5 (1) (2022)
Hanna Ostapska, Deepa Raju, Rachel Corsini, Melanie Lehoux, Ira Lacdao, Stephanie Gilbert, Piyanka Sivarajah, Natalie C Bamford, Perrin Baker, Fabrice N Gravelat, P Lynne Howell, Donald C Sheppard
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection. Antimicrobial agents and chemotherapy 66 (8) (2022)
Hanna Ostapska, François Le Mauff, Fabrice N Gravelat, Brendan D Snarr, Natalie C Bamford, Jaime C Van Loon, Geoffrey McKay, Dao Nguyen, P Lynne Howell, Donald C Sheppard
Co-Operative Biofilm Interactions between Aspergillus fumigatus and Pseudomonas aeruginosa through Secreted Galactosaminogalactan Exopolysaccharide. Journal of fungi (Basel, Switzerland) 8 (4) (2022)
Andreea A Gheorghita, Yancheng E Li, Elena N Kitova, Duong T Bui, Roland Pfoh, Kristin E Low, Gregory B Whitfield, Marthe T C Walvoort, Qingju Zhang, Jeroen D C Codée, John S Klassen, P Lynne Howell
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
Andreea A Gheorghita, Yancheng E Li, Elena N Kitova, Duong T Bui, Roland Pfoh, Kristin E Low, Gregory B Whitfield, Marthe T C Walvoort, Qingju Zhang, Jeroen D C Codée, John S Klassen, P Lynne Howell
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
Andreea A Gheorghita, Yancheng E Li, Elena N Kitova, Duong T Bui, Roland Pfoh, Kristin E Low, Gregory B Whitfield, Marthe T C Walvoort, Qingju Zhang, Jeroen D C Codée, John S Klassen, P Lynne Howell
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
François Le Mauff, Erum Razvi, Courtney Reichhardt, Piyanka Sivarajah, Matthew R Parsek, P Lynne Howell, Donald C Sheppard
Author Correction: The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine. Communications biology 5 (1) (2022)
Roland Pfoh, Adithya S Subramanian, Jingjing Huang, Dustin J Little, Adam Forman, Benjamin R DiFrancesco, Negar Balouchestani-Asli, Elena N Kitova, John S Klassen, Régis Pomès, Mark Nitz, P Lynne Howell
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing. PLoS pathogens 18 (8) (2022)
Julia E Dreifus, Lindsey O'Neal, Holly M Jacobs, Adithya S Subramanian, P Lynne Howell, Daniel J Wozniak, Matthew R Parsek
The Sia System and c-di-GMP Play a Crucial Role in Controlling Cell-Association of Psl in Planktonic P. aeruginosa. Journal of bacteriology (2022)
Andreea A Gheorghita, Yancheng E Li, Elena N Kitova, Duong T Bui, Roland Pfoh, Kristin E Low, Gregory B Whitfield, Marthe T C Walvoort, Qingju Zhang, Jeroen D C Codée, John S Klassen, P Lynne Howell
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
Andreea A Gheorghita, Yancheng E Li, Elena N Kitova, Duong T Bui, Roland Pfoh, Kristin E Low, Gregory B Whitfield, Marthe T C Walvoort, Qingju Zhang, Jeroen D C Codée, John S Klassen, P Lynne Howell
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
Gregory B Whitfield, P Lynne Howell
The Matrix Revisited: Opening Night for the Pel Polysaccharide Across Eubacterial Kingdoms. Microbiology insights 14 (2021)
Hanna Ostapska, Deepa Raju, Melanie Lehoux, Ira Lacdao, Stephanie Gilbert, Piyanka Sivarajah, Natalie C Bamford, Perrin Baker, Thi Tuyet Mai Nguyen, Caitlin A Zacharias, Fabrice N Gravelat, P Lynne Howell, Donald C Sheppard
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis. mBio 12 (5) (2021)
S Katharios-Lanwermeyer, G B Whitfield, P Lynne Howell, George A O'Toole
Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance. mBio 12 (1) (2021)
Gregory B Whitfield, Lindsey S Marmont, Cedoljub Bundalovic-Torma, Erum Razvi, Elyse J Roach, Cezar M Khursigara, John Parkinson, P Lynne Howell
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster. PLoS pathogens 16 (4) (2020)
James I P Stewart, Vinicius M Fava, Joshua D Kerkaert, Adithya S Subramanian, Fabrice N Gravelat, Melanie Lehoux, P Lynne Howell, Robert A Cramer, Donald C Sheppard
Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway. mBio 11 (1) (2020)
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grünewald, Samantha J Cargill, T Katherine Tamai, Yao Xu, Maria Luísa Jabbur, Rika Kojima, Melisa L Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology 3 (1) (2020)
Cedoljub Bundalovic-Torma, Gregory B Whitfield, Lindsey S Marmont, P Lynne Howell, John Parkinson
A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries. PLoS computational biology 16 (4) (2020)
Natalie C Bamford, François Le Mauff, Jaime C Van Loon, Hanna Ostapska, Brendan D Snarr, Yongzhen Zhang, Elena N Kitova, John S Klassen, Jeroen D C Codée, Donald C Sheppard, P Lynne Howell
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. Nature communications 11 (1) (2020)
Gregory B Whitfield, Lindsey S Marmont, Alex Ostaszewski, Jacquelyn D Rich, John C Whitney, Matthew R Parsek, Joe J Harrison, P Lynne Howell
Pel Polysaccharide Biosynthesis Requires an Inner Membrane Complex Comprised of PelD, PelE, PelF, and PelG. Journal of bacteriology 202 (8) (2020)
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grünewald, Samantha J Cargill, T Katherine Tamai, Yao Xu, Maria Luísa Jabbur, Rika Kojima, Melisa L Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology 3 (1) (2020)
Matthew McCallum, Samir Benlekbir, Sheryl Nguyen, Stephanie Tammam, John L Rubinstein, Lori L Burrows, P Lynne Howell
Multiple conformations facilitate PilT function in the type IV pilus. Nature communications 10 (1) (2019)
Dustin J Little, Roland Pfoh, François Le Mauff, Natalie C Bamford, Christina Notte, Perrin Baker, Manita Guragain, Howard Robinson, Gerald B Pier, Mark Nitz, Rajendar Deora, Donald C Sheppard, P Lynne Howell
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. PLoS pathogens 14 (4) (2018)
Hanna Ostapska, P Lynne Howell, Donald C Sheppard
Deacetylated microbial biofilm exopolysaccharides: It pays to be positive. PLoS pathogens 14 (12) (2018)

P Lynne Howell.css-eqlu8i{font-size:small;padding-left:4px;} (P L Howell)

Publication Activity (10 Years)

Top Topics

Top Venues

P Lynne Howell (P L Howell)