microRNA-21: a key modulator in oncogenic viral infections.
Guitian HeJuntao DingYong'e ZhangMengting CaiJing YangWilliam Chi Shing ChoYadong ZhengPublished in: RNA biology (2021)
Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.
Keyphrases
- sars cov
- cell proliferation
- long non coding rna
- transcription factor
- immune response
- long noncoding rna
- endothelial cells
- poor prognosis
- hepatitis b virus
- signaling pathway
- diffuse large b cell lymphoma
- epstein barr virus
- candida albicans
- reactive oxygen species
- dendritic cells
- high grade
- human immunodeficiency virus
- squamous cell
- nucleic acid
- antiretroviral therapy