Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.

Julia DelenkoXiangying XueProdyot K ChatterjeeNathaniel Hyman Andrew J Shih Robert P Adelson Polona Safaric Tepes Peter K Gregersen Christine N Metz

Published in: Reproductive biology and endocrinology : RB&E (2024)

These data provide insight into the mechanisms of action of quercetin on endometrial stromal cells and warrant future clinical trials to test quercetin and other senolytics for treating endometriosis.

Keyphrases

clinical trial
signaling pathway
cell proliferation
dna damage
electronic health record
big data
endothelial cells
pi k akt
randomized controlled trial
stress induced
phase ii
study protocol
data analysis
double blind
phase iii