Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway.

Jing LiLugen ZuoZhijun GengQingqing LiYang ChengZi YangRuohan ShiYueqing ZhouWenhu NieYueyue WangXiaofeng ZhangSitang GeXue SongJian-Guo Hu

Published in: Cell proliferation (2022)

The increase in Pygo2 may be related to mesenteric adipocyte poor differentiation and inflammatory features of CD, and Pygo2 inhibition could alleviate CD-like colitis by improving mesenteric lesions by regulating the Axin2/GSK3β pathway.

Keyphrases

adipose tissue
insulin resistance
signaling pathway
fatty acid
pi k akt
oxidative stress
ulcerative colitis
nk cells
mouse model
metabolic syndrome
type diabetes