Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial.

Arinilda Campos BragagnoliRaphael L C AraujoMauricio Wagner FerrazLucas Vieira Dos SantosKathia Cristina AbdallaFabiana ComarFlorinda Almeida SantosMarco Antonio OliveiraJosé Barreto Campello CarvalheiraFlávio Mavigner CárcanoJoão Paulo da Silveira Nogueira Lima

Published in: British journal of cancer (2021)

In this trial, metformin plus irinotecan demonstrated disease control in patients with refractory CRC. Further trials with optimised diarrhoea control are needed to confirm these results.

Keyphrases

clinical trial
phase ii
study protocol
phase iii
randomized controlled trial
double blind
irritable bowel syndrome