Prognostic relevance of HRDness gene expression signature in ovarian high-grade serous carcinoma; JGOG3025-TR2 study.

Shiro Takamatsu Kosuke YoshiharaTsukasa BabaMuneaki ShimadaHiroshi YoshidaHiroaki KajiyamaKatsutoshi OdaMasaki MandaiAikou OkamotoTakayuki EnomotoNoriomi Matsumura

Published in: British journal of cancer (2023)

The HRDness gene expression signature is associated with a good prognosis, while BRCA1 methylation is associated with a poor prognosis. The newly generated JGOG3025-TR2 dataset will be useful in future HGSC studies.

Keyphrases

gene expression
high grade
poor prognosis
dna methylation
long non coding rna
low grade
genome wide
current status
case control
breast cancer risk